產(chǎn)品屬性：
產(chǎn)品名稱 | EN40 |
規(guī)格 | 5mg、10mg、25mg、50mg、100mg |
貨號 | EY-01Y11806 |
Cas No.: 2094547-67-6
別名: N/A
化學(xué)名: N/A
分子式: C13H15NO2
分子量: 217.26
溶解度: DMSO: 5 mg/mL (23.01 mM); Ethanol: 2 mg/mL (9.21 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM[1]EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival[1].Cell Viability Assay[1] Cell Line:A549 cellsEN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice[1].Animal Model:SCID mice with A549 cells[1][1]. Counihan JL,et al.Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target.ACS Chem Biol. 2018 Aug 17;13(8):1970-1977
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